Deoxycholic acid (conjugate base deoxycholate), also known as cholanoic acid and 3α,12α-dihydroxy-5β-cholan-24-oic acid, is a bile acid.

Deoxycholic acid is one of the secondary bile acids, which are metabolic byproducts of intestinal bacteria. The two primary bile acids secreted by the liver are cholic acid and chenodeoxycholic acid. Bacteria metabolize chenodeoxycholic acid into the secondary bile acid lithocholic acid, and they metabolize cholic acid into deoxycholic acid. There are additional secondary bile acids, such as ursodeoxycholic acid. Deoxycholic acid is soluble in alcohol and acetic acid. When pure, it comes in a white to off-white crystalline powder form.

(1) Deoxycholic Acid is effective in disrupting and dissociating many types of protein interaction

(2) An emerging use of deoxycholate acid is as a biological detergent to lyse cells and solubilise cellular and membrane components.

(3) Deoxycholic Acid is used in the preparation and formulation of certain microbiological diagnostic media.

(4) Useful for elution or regeneration of certain kinds of affinity columns.

(1)Deoxycholic Acid Used in the emulsification of fats for the absorption in the intestine. Outside the body it is used in experimental basis of cholagogues and is also in use to prevent and dissolve gallstones.

(2) Sodium deoxycholate, the sodium salt of deoxycholic acid, is often used as a biological detergent to lyse cells and solubilise cellular and membrane components.

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