Xi'an Julong Bio-Tech Co., Ltd.
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Country: 
China (Mainland)
Business Type:Trading Company
Tel: +008618049624045
Tel: +008615877690239
Tel: +0086-18792996027
Tel: +008618049624045
Tel: +008618291367393
Tel: +8618629260427
Tel: +008617802922472
Tel: +008618729964529
Mobile: 18049624045
Tel: +008618049624045
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URL: http://LookChem.com
Province/state: Shaan xi
City: xi'an
Street: Xi'an
MaxCard:
Ms.Amber Ms.Florence Ms.Lisa Ms.EllenCAS NO.159351-69-6
99%(1-24)Kilogram99%(25-99)Kilogram99%(100-500)Kilogram
Xi'an Julong Bio-Tech Co., Ltd. is located in Xi'an City, Shaanxi Province, China. It is a biotechnology enterprise engaged in the research, development, production and sales of animal and plant extracts, cosmetics, pharmaceutical raw materials and intermediates. The company has complete experimental facilities. And advanced testing instruments ensure the stability of product quality from all aspects. The company has a complete sales service system, the products are exported to countries all over the world, and have won a good international reputation with excellent quality and excellent service.
The company has been adhering to the basic principles of "integrity, quality, service, and win-win" to serve customers, constantly strict requirements, set goals, and implement win-win development.
1. All inquiries will be replied within 12 hours.
2. Dedication to quality, supply & service.
3. Strictly on selecting raw materials.
3. OEM/ODM Available.
4. Reasonable & competitive price, fast lead time.
5. Sample is available for your evaluation & Formulation development.
6. Faster delivery:Sample order in stock and 3-7 days for bulk production.
7. We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS. Or you also can choose your own shipping forwarder.
8. After-Sale Service:
1) International Authorized Third-Party Test For The Products You Demand.
2) 30 Days Warranty of quality of goods.
| Name | Everolimus |
| CAS No | 159351-69-6 |
| Appearance | white powder |
| Molecular Formula | C53H83NO14 |
| Molecular Weight | 914.18 |
| Assay | 98%min |
Everolimus (RAD001) is an orally active derivative of rapamycin that inhibits Ser / Thr kinase mTOR [1]. In sensitive mouse B16/BL6 melanoma (IC50, 0.7 nM) and insensitive human cervical KB-31 (IC50, 1,778 nM), the antiproliferative concentration of everolimus resulted in a total of S6K1 and substrate S6. Dephosphorylation and changes in mobility. 4E-BP1, indicating a decrease in phosphorylation status [2]. Everolimus showed dose-dependent inhibition in total cells and stem cells from the BT474 cell line and primary breast cancer cells, albeit with varying degrees of growth inhibition. Compared with total cells, everolimus had a poor inhibitory effect on stem cell growth at all concentrations tested (P < 0.001). The IC50 values of everolimus against BT474 and primary CSC were 2,054 and 3,227 nM, respectively, or 29 and 21 times the IC50 values of their respective total cells, respectively.
Function
Everolimus is indicated for the treatment of postmenopausal women with advanced hormone receptor-positive, HER2-negative breast cancer (advanced HR+ BC) in combination with exemestane, after failure of treatment with letrozole or anastrozole. Indicated for the treatment of adult patients with progressive neuroendocrine tumors of pancreatic origin (PNET) with unresectable, locally advanced or metastatic disease. Indicated for the treatment of adult patients with advanced renal cell carcinoma (RCC) after failure of treatment with sunitinib or sorafenib. Indicated for the treatment of adult patients with renal angiomyolipoma and tuberous sclerosis complex (TSC), not requiring immediate surgery. Indicated in pediatric and adult patients with tuberous sclerosis complex (TSC) for the treatment of subependymal giant cell astrocytoma (SEGA) that requires therapeutic intervention but cannot be curatively resected.
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Suitable for under 50kg |
Suitable for more than 50kg |
Suitable for more than 500kg |
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Xi'an Julong Bio-Tech Co., Ltd. is located in Xi'an City, Shaanxi Province, China. It is a biotechnology enterprise engaged in the research, development, production and sales of animal and plant extracts, cosmetics, pharmaceutical raw materials and intermediates. The company has complete experimental facilities. And advanced testing instruments ensure the stability of product quality from all aspects. The company has a complete sales service system, the products are exported to countries all over the world, and have won a good international reputation with excellent quality and excellent service.
The company has been adhering to the basic principles of "integrity, quality, service, and win-win" to serve customers, constantly strict requirements, set goals, and implement win-win development.
1. All inquiries will be replied within 12 hours.
2. Dedication to quality, supply & service.
3. Strictly on selecting raw materials.
3. OEM/ODM Available.
4. Reasonable & competitive price, fast lead time.
5. Sample is available for your evaluation & Formulation development.
6. Faster delivery:Sample order in stock and 3-7 days for bulk production.
7. We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS. Or you also can choose your own shipping forwarder.
8. After-Sale Service:
1) International Authorized Third-Party Test For The Products You Demand.
2) 30 Days Warranty of quality of goods.
Q: What's your MOQ
A: For the high value product, our MOQ starts from 1g and generally starts from 10gs. For other low, price product, our MOQ starts from 100g and 1kg.
Q: Is there a discount
A: Yes, for larger quantity, we always support with better price.
Q: How to confirm the Product Quality before placing orders
A: You can get free samples for some products, you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests, we will manufacture the products according to your requests
Q: How to start orders or make payments
A: You can send our your Purchase order (if your company has), or just send a simple confirmation by email or by Trade Manager, and we will send you Proforma Invoice with our bank details for your confirmation, then you can make payment accordingly.
Q: How do you treat quality complaint
First of all, our quality control will reduce the quality problem to near zero. If there is a quality problem caused by us, we will send you free goods for replacement or refund your loss.
