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CAS NO.171596-29-5
90%(1-10)Kilogram
Tadalafil reasonable price 171596-29-5 Hot Sale Good Supplier In China
"Indications"
tadana non-use for the treatment of erectile dysfunction (ED) and pulmonary hypertension in men.
Pharmacological action and mechanism of action:
erectile dysfunction: Hedanafi and Sidina non-selective type 5 phosphate diesterase (PDE5), but its structure is different from the latter, high-fat diet will not interfere with its absorption. Under sexual stimulation, nitric oxide synthase (NOS) catalytic substrate L-Arginine in penile nerve endings and vascular endothelial cells synthesizes nitric oxide (NO). NO activates the bird glycoside cyclotase, which converts the bird glycoside triphosphate into cGMP, thereby activating the cyclophosphate ostensitated protein kinase, resulting in a decrease in the concentration of calcium ions in smooth muscle cells, and the smooth muscle relaxation of the penis sponge body resulting in erections. Type 5 diesterase (PDE5) degrades cGMP into a physiologically inactive product that weakens the penis. He dana non-inhibits PDE5 degradation, causing cGMP to accumulate, making the penis sponge body smooth muscle relaxation, resulting in penis erection. Since nitrate drugs are NO donors, the combination of clinical contraindications can significantly increase cGMP levels after non-use with dana, resulting in severe hypotension.
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