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CAS NO.317318-70-0
1(10-50)Gram1(50-100)Gram1(100-500)Gram
Good Supplier In China 317318-70-0 in stock GW501516 Wholesaler
In vitro research
GW501516isshowntosnostentandselectivePPAαagonistsknownwithanEC50of1.1nMagainstSTPARαand1000-foldselectivityoverthehumansubtypes, PPARαand-γ.GW501516exertsanti-inflammatoryeffectsinmouseculturedproximaltubular(mProx)cells. GW501516inhibitspalmitate-and TNFα-inducedincreasesinMCP-1mRNAexpressioninadose-dependentmanner.
Internal research
GW501516causesimpairedbeonformation,leadingtodecreasedBMDanddeteriorationofbonepropertiesinOVXrats.GW501516attenuatesinterstitialinflammationandproximaltubularcelldamageinaprotein-overloadmousenephropathymodel,GW501516treatmentenhancesrunningenduranceandtheproportionofsuccinatedehydrogenase(SDH)-positivemusclefibresinbothtrainedanduntrainedmice.
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