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CAS NO.10540-29-1
oil(10-49)bottleoil(50-99)bottleoil(100-500)bottlepowder(10-49)Grampowder(50-99)Grampowder(100-500)Gram
in bulk supply Reliable quality Tamoxifen Best price 10540-29-1
Tamoxifen is a non-steroidal anti-estrogen drug. The structure is similar to that of estrogen, with two isomers, type Z and type E. The physical and chemical properties of the two are different, physiological activity is also different, E-type has weak estrogen activity, Z-type has anti-estrogen effect. If there is an estrogen receptor (ER) in a breast cancer cell, the estrogen enters the tumor cell and binds to it, prompting the dna and mRNA synthesis of the tumor cell and stimulating the growth of the tumor cell. The moxifen Z isomer enters the cell and binds to ER competition, forming a receptor complex that blocks the action of estrogen, thereby inhibiting the proliferation of breast cancer cells. Clinically mainly used in breast cancer patients with high estrogen levels, it is combined with androgens and other anti-tumor drugs (such as amycin, etc.) to improve the efficacy of advanced postmenopausal breast cancer. Oral: 10 to 20 mg, 2 times a day. Common adverse reactions are facial redness, vulva itching, occasional vaginal bleeding, a few can have headache, fluid retention, long-term use can appear retinal disorders, vision loss, in addition to bone marrow inhibition and gastrointestinal reactions. The treatment of tamoxifen for breast cancer can reduce the mortality and recurrence rate of estrogen-dependent breast cancer patients, and has good application prospects. Another endocrine therapy drug aromatase inhibitor, it can inhibit the role of aromatase, prevent the adrenal gland secretion of male diazepam in the peripheral tissue (fat, skin, muscle) into estrogen, further reduce the level of estrogen in postmenopausal women, it is currently one of the important means to treat postmenopausal estrogen receptor-positive breast cancer.
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