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Country: China (Mainland)
Business Type:Trading Company
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Province/state: Shaan xi
City: xi'an
Street: Xi'an
MaxCard:
CAS NO.107868-30-4
Powder(1-10)Kilogram
1. Who are we
We are based in Shaanxi, China, start from 2018,sell to North America(00.00%),
Western Europe(00.00%),South America(00.00%),Southeast Asia(00.00%),
Eastern Europe(00.00%). There are total about 11-50 people in our office.
2. How can we guarantee quality
Always a pre-production sample before mass production;
Always final Inspection before shipment;
3.What can you buy from us
Plant Extracts,Cosmetics Raw Materials,Vitamin Raw Materials,Pharmaceutical Raw Materials and Intermediates.
4. Why should you buy from us not from other suppliers
Our company mainly devoted in producing pharmacetical intermediates , Vitamins , and health supplement ,
the quality and technical content can reach the advance level in China .
Our products are sold well in China as well as in more than 20 countries.
5. What services can we provide
Accepted Delivery Terms: FOB,CFR,CIF,EXW,Express Delivery;
Accepted Payment Currency:USD,EUR,JPY,CAD,AUD,HKD,GBP,CNY,CHF;
Accepted Payment Type: T/T,L/C,MoneyGram,Credit Card,,Cash,Escrow;
Language Spoken:English,Chinese,Spanish,Japanese,Portuguese,German,Arabic,French,Russian,Korean,Hindi,Italian.
6.We promise our customer following items
Support product customization:
We can provide OEM&ODM , Because we have a professional design team.
Reasonable price:
We provide high quality products with competitive price in china,
Low MOQ:
No worry about the low moq, our moq is 1 gram or lower.
Good and efficient service,Fast Delivery
Fast respond save client's time, we promise to reply inquiry in 24 hours including holidays and send quotation sheet and other documents in 48 hours.
Super-good quality
We have strict quality control system .Good reputation in Market , And have the Third party test report is available.
Bodybuilding Oil Exemestane Aromasin-5
CAS: | 107868-30-4 |
MF: | C20H24O2 |
Application: | An antineoplastic(hormonal) |
Purity: | 99% |
Exemestane(FCE 24304) is an aromatase inhibitor, inhibits human placental and rat ovarian aromatase with IC50 of
30 nM and 40 nM, respectively.Target: AromataseApproved: October 2005Exemestane competitively inhibits and
time-dependently inactivates of human placental aromatase with Ki of 4.3 nM. Exemestane displaces DHT from
rat prostate androgen receptor with IC50 of 0.9 μM . Exemestane (1 μM) increases alkaline phosphatase activity in
hFOB and Saos-2 cells and induces the expression of MYBL2, OSTM1, HOXD11, ADCYAP1R1, and glypican 2 in hFOB
cells . Exemestane causes aromatase degradation in a dose-responsive manner in MCF-7aro cells .Exemestane
increases lumbar spine BMD by 14.0% in OVX rats at dose of 100 mg/kg. Exemestane (100 mg/kg) and
17-hydroexemestane (20 mg/kg) significantly reduces an ovariectomy-induced increase in serum pyridinoline and
serum osteocalcin in rats and causes significant reductions of serum cholesterol and low-density lipoprotein
cholesterol inOVX rats .Exemestane (20 mg/kg/day s.c.) induces 26% complete (CR) and 18% partial (PR) tumor
regressions in rats with 7,12-dimethylbenzanthracene (DMBA)-induced mammary tumors .
Application & Function
Exemestane (trade name aromasin) is a drug used to treat breast cancer. it is a member of the class of drugs known as
aromatase inhibitors. some breast cancers require estrogen to grow. those cancers have estrogen receptors (ers), and
are called er-positive. they may also be called estrogen-responsive,hormonally-responsive, hormone-receptor-positive.
aromatase is an enzyme that synthesizes estrogen. aromatase inhibitors block the synthesis of estrogen. this lowers
the estrogen level, and slows the growth of cancers.
1. Exemestane is an oral steroidal aromatase inhibitor that is used in er-positive breast cancer in addition to surgery
and/or radiation in post-menopausal women.
2. It acts as a false substrate for the aromatase enzyme, and is processed to an intermediate that binds irreversibly to
the active site of the enzyme causing its inactivation, an effect also known as "suicide inhibition."
3. By being structurally similar to enzyme targets, exemestane permanently binds to the enzymes, preventing them
from converting androgen into estrogen
Item |
Specification |
Results |
Appearance Identification Residue on ignition Heavy metals Water Specific optical rotation Impurity Spirooxiran 1 Spirooxiran 2 Exemestane related(compound c) Exemestane related(compound a) Any unspecified impurity Total impurity Assay(hplc) Micron |
white crystalline powder ir rt (hplc) 0.1% max 10ppm max 0.5% max +290° to +300° 0.15% max 0.15% max 0.15% max 0.15% max 0.1% max 0.5% max 98% to 10.2% 100% less than 20μm |
Conform Conform Conform 0.04% Conform 0.03% +290.86° Not Detected Not Detected Not Detected Not Detected 0.05% 0.25% 100.02% Conform |
Conclusion: up to standard for usp pending monograph |
1. All inquiries will be replied within 12 hours.
2. Dedication to quality, supply & service.
3. Strictly on selecting raw materials.
4. OEM/ODM Available.
5. Reasonable & competitive price, fast lead time.
6. Sample is available for your evaluation & Formulation development.
7. Faster delivery:Sample order in stock and 3-7 days for bulk production.
8.We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS. Or you also can choose your own shipping forwarder
9. After-Sale Service:
1) International Authorized Third-Party Test For The Products You Demand.
2) 30 Days Warranty of quality of goods.
Delivery & Payment Terms
Julong Bio-Tech Co., Ltd. is located in Xi'an City, Shaanxi Province, China. It is a biotechnology enterprise engaged
in the research, development, production and sales of animal and plant extracts, cosmetics, pharmaceutical raw materials
and intermediates. The company has complete experimental facilities. And advanced testing instruments ensure the stability
of product quality from all aspects. The company has a complete sales service system, the products are exported to countries
all over the world, and have won a good international reputation with excellent quality and excellent service.
The company has been adhering to the basic principles of "integrity, quality, service, and win-win" to serve customers,
constantly strict requirements, set goals, and implement win-win development.
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