Xi'an Julong Bio-Tech Co., Ltd.
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Ms.Amber Ms.Florence Ms.Lisa Ms.EllenCAS NO.161973-10-0
Powder(1-50)KilogramPowder(51-500)KilogramPowder(500-1000)Kilogram
1. Who are we
We are based in Shaanxi, China, start from 2018,sell to North America(00.00%),
Western Europe(00.00%),South America(00.00%),Southeast Asia(00.00%),
Eastern Europe(00.00%). There are total about 11-50 people in our office.
2. How can we guarantee quality
Always a pre-production sample before mass production;
Always final Inspection before shipment;
3.What can you buy from us
Plant Extracts,Cosmetics Raw Materials,Vitamin Raw Materials,Pharmaceutical Raw Materials and Intermediates.
4. Why should you buy from us not from other suppliers
Our company mainly devoted in producing pharmacetical intermediates , Vitamins , and health supplement ,
the quality and technical content can reach the advance level in China .
Our products are sold well in China as well as in more than 20 countries.
5. What services can we provide
Accepted Delivery Terms: FOB,CFR,CIF,EXW,Express Delivery;
Accepted Payment Currency:USD,EUR,JPY,CAD,AUD,HKD,GBP,CNY,CHF;
Accepted Payment Type: T/T,L/C,MoneyGram,Credit Card,,Cash,Escrow;
Language Spoken:English,Chinese,Spanish,Japanese,Portuguese,German,Arabic,French,Russian,Korean,Hindi,Italian.
6.We promise our customer following items
Support product customization:
We can provide OEM&ODM , Because we have a professional design team.
Reasonable price:
We provide high quality products with competitive price in china,
Low MOQ:
No worry about the low moq, our moq is 1 gram or lower.
Good and efficient service,Fast Delivery
Fast respond save client's time, we promise to reply inquiry in 24 hours including holidays and send quotation sheet and other documents in 48 hours.
Super-good quality
We have strict quality control system .Good reputation in Market , And have the Third party test report is available.
What's CAS 161973-10-0 Esomeprazole Magnesium Powder
| Product Name: | Esomeprazole magnesium |
| Synonyms: | Esomeprazole magnesium 5-Methoxy-2-[(S)-(4-methoxy-3,5-dimethyl-2-pyridinylmethyl)sulfinyl]-1H-benzimidazole magnesium salt;Esomeprazole Magnesium(Random Configuration);Esomeprazole magnesium;Magnesium 5-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]benzimidazol-1-ide;Bis(5-methoxy-2-{(S)-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}benzimidazol-1-ide) magnesium;Chebi:50309;EsoMeprazole MagnesiuM(NexiuM);EsMeprazole Magne-siuM Trihydrate |
| CAS: | 161973-10-0 |
| MF: | 2(C17H18N3O3S)2.Mg |
| MW: | 713.12 |
| EINECS: | 627-029-7 |
Esomeprazole is the latest in the class of agents called the protonpump inhibitors(PPIs). These drugs inhibit gastric
hydrochloric acid secretion by binding to hydrogen- potassium adenosinetriphosphatase (H+, K+-ATPase) in gastric
parietal cells. The PPIs' ability to provide rapid symptomatic control and their demonstrated efficacy in healing erosive
esophagitis have led them to be viewed as agents of choice for treating patients with gastric acid-related diseases,
including gastroesophageal reflux disease(GERD), gastric ulcers, and duodenal ulcers. In addition, these agents have
been shown to be effective in the treatment of Zollinger-Ellison syndrome and Barrett's esophagus. Esomeprazole is
the fourth PPI to be approved for use in the United States, following omeprazole; the other available PPIs are lansoprazole,
pantoprazole, and rabeprazole. PPIs have similar chemical structures and a shared mechanism of action. Esomeprazole,
the S-isomer of omeprazole, is the first PPI developed as a single optical isomer. Esomeprazole has an improved pharmacokinetic
profile over omeprazole (a racemic mixture of Sand Roptical isomers), resulting in more potent acid suppression.
Esomeprazole, like the other PPIs, does this by accumulating in the secretory canaliculus of the parietal cell when the cell
is secreting hydrochloric acid. After accumulating in this acidic environment, these agents are converted to a tetracyclic
sulfenamide, which binds covalently to sulfhydryl groups of H+, K+-ATPase, rendering it inactive. The enzyme's inactivation
blocks the final step of hydrochloric acid secretion into the stomach, resulting in a higher gastric pH. The covalent binding
of PPIs to H+, K+-ATPase is irreversible; restoration of gastric acid production depends on the rate of de novo proton-pump
regeneration, not how long plasma drug levels are maintained.
Application & Function
Esomeprazole magnesium (esomeprazole magnesium), also known as omeprazole, esomeprazole he left Esso chemical name,
(S) - (-) -5- methoxy -2-{[(4- methyl two methoxy -3,5- -2- pyridyl) methyl] sulfinyl benzimidazole}-1H- magnesium salt, is a
new type of proton pump inhibitor, can the inhibition of H+/K+-ATP activity, mainly used for the treatment of gastric acid
hypersecretion induced gastric ulcer, duodenal ulcer and reflux esophagitis clinical digestive system disease.
1. For gastroesophageal reflux disease (GERD).
2.Treatment of erosive reflux esophagitis in cases.
3. long term maintenance of relapse in patients with esophagitis who have been cured.
4. Symptom control of gastroesophageal reflux disease (GERD)
5. combined with appropriate antimicrobial therapy for the eradication of Helicobacter pylori infection related peptic ulcer healing,
and to prevent recurrence.
6. the risk of gastric ulcer is reduced in patients receiving continuous NSAID treatment.
7. for the treatment of liver and stomach of the chest and diaphragm, stomach burning pain.
8. for the treatment of stomachache Tunsuan, dysphagia, hiccup.
| Items | Specification | Results |
| Appearance | White powder of crystalline powder | White crystalline powder |
| Specific optical rotation | +36°~+43° | +41.0° |
| IDENTIFICATION | ||
| HPLC | The retention time of the major peak of the sample solution corresponds to that of the system suitability solution,as obtained in the test for Enatiomeric. | Complies |
| UV | The UV absorption spectra of the test solution exhibit maximum absorption at 266nm,273nm and 282nm. | Complies |
| IR | IR spectrum of sample conforms to that of reference standard. | Complies |
| Reaction of chlorides | A solution of it responds to the tests for Chloride. | Complies |
| TESTS | ||
| Appearance of solution | Clear;not more intensely coloured than Y2 or GY2 | Complies |
| Related substances | ||
| Impurity A | NMT 0.2% | 0.01% |
| Impurity B | NMT 0.2% | Not found |
| Impurity C+D | NMT 0.8% | 0.02% |
| Impurity F | NMT 0.2% | Not found |
| 0.03%(RRT:0.95) | ||
| Any other detectable impurity | NMT 0.1% | 0.03%(RRT:1.2) |
| 0.03%(RRT:1.3) | ||
| Total impurities | NMT 1.5% | 0.15% |
| Impurity E | NMT 0.2% | Not found |
| Enantiomeric | NMT 1.0% | 0.02% |
| Residual solvents | ||
| Methanol | NMT 0.3% | Not found |
| Ethanol | NMT 0.5% | 0.0636% |
| n-Butanol | NMT 0.5% | Not found |
| Tetrahydrofuran | NMT 0.072% | Not found |
| Toluene | NMT 0.089% | Not found |
| Ethyl acetate | NMT 0.5% | Not found |
| Ether | NMT 0.5% | 0.0007% |
| Chloroben | NMT 0.036% | Not found |
| N-methyl formamide | NMT 0.088% | Not found |
| Loss on drying | NMT 0.5% | 0.08% |
| Residue on ignition | NMT 0.1% | 0.03% |
| Heavy metals | NMT 0.001% | Less than 0.001% |
| Assay(on anhydrous basis) | NLT 98.5% of C17H17Cl2N·HCl | 99.6% |
1. All inquiries will be replied within 12 hours.
2. Dedication to quality, supply & service.
3. Strictly on selecting raw materials.
4. OEM/ODM Available.
5. Reasonable & competitive price, fast lead time.
6. Sample is available for your evaluation & Formulation development.
7. Faster delivery:Sample order in stock and 3-7 days for bulk production.
8.We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS. Or you also can choose your own shipping forwarder
9. After-Sale Service:
1) International Authorized Third-Party Test For The Products You Demand.
2) 30 Days Warranty of quality of goods.
Delivery & Payment Terms
Julong Bio-Tech Co., Ltd. is located in Xi'an City, Shaanxi Province, China. It is a biotechnology enterprise engaged
in the research, development, production and sales of animal and plant extracts, cosmetics, pharmaceutical raw materials
and intermediates. The company has complete experimental facilities. And advanced testing instruments ensure the stability
of product quality from all aspects. The company has a complete sales service system, the products are exported to countries
all over the world, and have won a good international reputation with excellent quality and excellent service.
The company has been adhering to the basic principles of "integrity, quality, service, and win-win" to serve customers,
constantly strict requirements, set goals, and implement win-win development.
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