Xi'an Julong Bio-Tech Co., Ltd.
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Business Type:Trading Company
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Ms.Amber Ms.Florence Ms.Lisa Ms.EllenCAS NO.298-50-0
99%(1-99)Kilogram99%(100-500)Kilogram
We promise our customer following items:
1.Support product customization:
We can provide OEM&ODM , Because we have a professional design team
2.Reasonable price:
We provide high quality products with competitive price in china,
3.Low moq:
No worry about the low moq, our moq is 1 gram or lower.
3.Good and efficient service,Fast Delivery
Fast respond save client's time, we promise to reply inquiry in 24 hours including holidays and send quotation sheet and other documents in 48 hours.
4.Super-good quality
We have strict quality control system .Good reputation in Market , And have the Third party test report is available
Pls contact us
If you have any further questions or need a sample,Please do not hesitate to contact us.
Xi'an Julong Bio-Tech Co., Ltd.
| Product Name: | PROPARACAINE |
| Synonyms: | PROPARACAINE;(2-hydroxyethyl)diisopropylmethyl-ammoniuxanthene-9-carboxylate(ester);2-propanaminium,n-methyl-n-(1-methylethyl)-n-(2-((9h-xanthen-9-ylcarbonyl)oxy);propantheline;[2-[(9H-Xanthen-9-ylcarbonyl)oxy]ethyl]diisopropylmethylaminium;Diisopropylmethyl[2-(9H-xanthene-9-ylcarbonyloxy)ethyl]aminium;diisopropyl-methyl-[2-(9H-xanthene-9-carbonyloxy)ethyl]ammonium;methyl-di(propan-2-yl)-[2-(9H-xanthen-9-ylcarbonyloxy)ethyl]azanium |
| CAS: | 298-50-0 |
| MF: | C16H26N2O3 |
| MW: | 294.39 |
| EINECS: | 206-063-2 |
| Product Categories: | |
| Mol File: | 298-50-0.mol |
Proparacaine Hydrochloride Ophthalmic Solution is a rapid acting local anesthetic suitable for ophthalmic use. With a single drop, the onset of anesthesia begins within 30 seconds and persists for 15 minutes or longer.
The main site of anesthetic action is the nerve cell membrane where proparacaine interferes with the large transient increase in the membrane permeability to sodium ions that is normally produced by a slight depolarization of the membrane. As the anesthetic action progressively develops in a nerve, the threshold for electrical stimulation gradually increases and the safety factor for conduction decreases; when this action is sufficiently well developed, block of conduction is produced.
The exact mechanism whereby proparacaine and other local anesthetics influence the permeability of the cell membrane is unknown; however, several studies indicate that local anesthetics may limit sodium ion permeability by closing the pores through which the ions migrate in the lipid layer of the nerve cell membrane. This limitation prevents the fundamental change necessary for the generation of the action potential.
Proparacaine Hydrochloride Ophthalmic Solution is indicated for topical anesthesia in ophthalmic practice. Representative ophthalmic procedures in which the preparation provides good local anesthesia include measurement of intraocular pressure (tonometry), removal of foreign bodies and sutures from the cornea, conjunctival scraping in diagnosis and gonioscopic examination; it is also indicated for use as a topical anesthetic prior to surgical operations such as cataract extraction.
Pramocaine hydrochloride is a topical anesthetic, and used as an antipruritic.
Proparacaine Hydrochloride is a voltage-gated sodium channels antagonist with ED50 of 3.4 mM.IC50 Value: 3.4 mM(ED50) [1]Target: Sodium Channelin vitro: Proparacaine is more potent and less toxic than cocaine [1]. Proparacaine significantly increases in FHV-1 (P < 0.01), C. felis, and 28S rDNA Ct values when fusidic acid is used [2].in vivo: Proparacaine inhibits corneal epithelial migration and adhesion through alteration of the actin cytoskeleton [3]. Proparacaine acts like bupivacaine or lidocaine and produces dose-related spinal blockades of motor function, proprioception and nociception. Intrathecal proxymetacaine also produces longer sensory blockade than motor blockade [4].
| Anesthetic / Pain Killer | |||
| Tetracaine Base | 94-24-6 | Prilocaine hydrochloride | 1786-81-8 |
| Tetracaine hydrochloride | 136-47-0 | Proparacaine hydrochloride | 5875/6/9 |
| Lidocaine hydrochloride | 73-78-9 | Pramoxine hydrochloride | 637-58-1 |
| Linocaine Base | 137-58-6 | Procainamide hydrochloride | 614-39-1 |
| Benzocaine hydrochloride | 23239-88-5 | Ropivacaine hydrochloride | 98717-15-8 |
| Benzocaine Base | 94-09-7 | Articaine hydrochloride | 23964-57-0 |
| Procaine | 59-46-1 | Bupivacaine | 2180-92-9 |
| Procaine hydrochloride | 1951/5/8 | Mepivacaine hydrochloride/Carbocaine | 1722-62-9 |
| Prilocaine | 721-50-6 | dibucaine hydrochloride | 61-12-1 |
| Items | Standards | Results |
| Appearance | White to light yellow crystalline powder | Complies |
| Identification | It should be Nitrogen base reaction | Complies |
| By UV | Complies | |
| Should display the reaction of chloride differentiated | Complies | |
| Solubility | Should dissolved in water, warm ethanol and methanol, insoluble in ether and benzene, the solution is neutral to litmus | Complies |
| Melting Point | 178ºC~185ºC | 180.3~182.1ºC |
| Loss on Drying | ≤ 0.50% | 0.14% |
| Residue on Ignition | ≤ 0.15% | 0.03% |
| Residual Solvents | DMF: ≤880ppm | ND |
| Ethanol: ≤5000ppm | ND | |
| Acetone: ≤5000ppm | ND | |
| Isopropanol: ≤5000ppm | ND | |
| Toluene: ≤890ppm | ND | |
| Methanol: ≤3000ppm | ND | |
| Related Substances | If the impurities are detected, then the total amount of the impurities should be not more than 2.0%. | Complies |
| Assay (on the anhydrous basis) | 97.0%~103.0% | 99.67% |
| Reference Standard | USP35 Standard | |
| Conclusion | The product complied to USP35 standard. | |
| Storage | Preserve in tight,light-resistant containers in a cool place | |
Q: What's your MOQ
A: For the high value product, our MOQ starts from 1g and generally starts from 10gs. For other low, price product, our MOQ starts from 100g and 1kg.
Q: Is there a discount
A: Yes, for larger quantity, we always support with better price.
Q: How to confirm the Product Quality before placing orders
A: You can get free samples for some products, you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests, we will manufacture the products according to your requests
Q: How to start orders or make payments
A: You can send our your Purchase order (if your company has), or just send a simple confirmation by email or by Trade Manager, and we will send you Proforma Invoice with our bank details for your confirmation, then you can make payment accordingly.
Q: How do you treat quality complaint
First of all, our quality control will reduce the quality problem to near zero. If there is a quality problem caused by us, we will send you free goods for replacement or refund your loss.
