Keywords

• Saxagliptin
• 361442-04-8
• Saxagliptin Price

Quick Details

• ProName: High quality Saxagliptin(361442-04-8) ...
• CasNo: 361442-04-8
• Molecular Formula: C18H25N3O2
• Appearance: white powder
• Application: research purpose, pharmaceutical raw m...
• DeliveryTime: 7-10 days
• PackAge: 25kg/drum
• Port: Any port in China
• ProductionCapacity: 50 Kilogram/Month
• Purity: 99%
• Storage: 2 ℃ to 8 ℃
• Transportation: by Sea,by land, by air
• LimitNum: 1 Gram
• Related Substances: 0.1
• Residue on Ignition: 0.1
• Heavy Metal: 10ppm
• Valid Period: 2 years
• Sample: Available
• Stock: Available
• Brand: JULONG
• COA: Available
• Certificate: ISO/GMP
• Packing: 20&25kgs or 1kg
• Grade: Phamaceutical Grade

Superiority

We promise our customer following items:

1.Support product customization:

We can provide OEM&ODM , Because we have a professional design team


2.Reasonable price:
We provide high quality products with competitive price in china,

3.Low MOQ:
No worry about the low moq, our moq is 1 gram or lower.

3.Good and efficient service,Fast Delivery
Fast respond save client's time, we promise to reply inquiry in 24 hours including holidays and send quotation sheet and other documents in 48 hours.

4.Super-good quality
We have strict quality control system .Good reputation in Market , And have the Third party test report is available


Pls contact us

If you have any further questions or need a sample,Please do not hesitate to contact us.

Xi'an Julong Bio-Tech Co., Ltd.

Details

1. Strong backup of facotry: high R&D ability, favorable quality and competitive price

2. Stock avaliability

3. Flexible business way, like payment term and product delivery

4. Fast response 24*7

5. A good troubleshooter/very positive attitude for after service

Saxagliptin is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs.This compound belongs to the class of organic compounds known as alpha amino acid amides. These are amide derivatives of alpha amino acids.

Pharmacodynamics:

Post-administration of saxagliptin, GLP-1 and GIP levels rise up to 2- to 3- fold. Because it is very selective of DPP-4 inhibition, there are fewer systemic side effects. Saxagliptin inhibits DPP-4 enzyme activity for a 24-hour period. It also decreased glucagon concentrations and increased glucose-dependent insulin secretion from pancreatic beta cells. The half maximal inhibitory concentration (IC50) is 0.5 nmol/L. Saxagliptin did not prolong the QTc interval to a clinically significant degree.

Mechanism of Action:

Saxagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor antidiabetic for the treatment of type 2 diabetes. DPP-4 inhibitors are a class of compounds that work by affecting the action of natural hormones in the body called incretins. Incretins decrease blood sugar by increasing consumption of sugar by the body, mainly through increasing insulin production in the pancreas, and by reducing production of sugar by the liver. [Bristol-Myers Squibb Press Release] DPP-4 is a membrane associated peptidase which is found in many tissues, lymphocytes and plasma. DPP-4 has two main mechanisms of action, an enzymatic function and another mechanism where DPP-4 binds adenosine deaminase, which conveys intracellular signals via dimerization when activated. Saxagliptin forms a reversible, histidine-assisted covalent bond between its nitrile group and the S630 hydroxyl oxygen on DPP-4. The inhibition of DPP-4 increases levels active of glucagon like peptide 1 (GLP-1), which inhibits glucagon production from pancreatic alpha cells and increases production of insulin from pancreatic beta cells.

 

Q: What's your MOQ
A: For the high value product, our MOQ starts from 1g and generally starts from 10gs. For other low, price product, our MOQ starts from 100g and 1kg.

Q: Is there a discount
A: Yes, for larger quantity, we always support with better price. 

Q: How to confirm the Product Quality before placing orders
A: You can get free samples for some products, you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests, we will manufacture the products according to your requests

Q: How to start orders or make payments
A: You can send our your Purchase order (if your company has), or just send a simple confirmation by email or by Trade Manager, and we will send you Proforma Invoice with our bank details for your confirmation, then you can make payment accordingly.

Q: How do you treat quality complaint
First of all, our quality control will reduce the quality problem to near zero. If there is a quality problem caused by us, we will send you free goods for replacement or refund your loss.