Xi'an Julong Bio-Tech Co., Ltd.
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China (Mainland)
Business Type:Trading Company
Tel: +008618049624045
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URL: http://LookChem.com
Province/state: Shaan xi
City: xi'an
Street: Xi'an
MaxCard:
Ms.Amber Ms.Florence Ms.Lisa Ms.EllenCAS NO.50-56-6
Powder(5-100)MilligramPowder(100-500)Milligram
1. Who are we
We are based in Shaanxi, China, start from 2018,sell to North America(00.00%),
Western Europe(00.00%),South America(00.00%),Southeast Asia(00.00%),
Eastern Europe(00.00%). There are total about 11-50 people in our office.
2. How can we guarantee quality
Always a pre-production sample before mass production;
Always final Inspection before shipment;
3.What can you buy from us
Plant Extracts,Cosmetics Raw Materials,Vitamin Raw Materials,Pharmaceutical Raw Materials and Intermediates.
4. Why should you buy from us not from other suppliers
Our company mainly devoted in producing pharmacetical intermediates , Vitamins , and health supplement ,
the quality and technical content can reach the advance level in China .
Our products are sold well in China as well as in more than 20 countries.
5. What services can we provide
Accepted Delivery Terms: FOB,CFR,CIF,EXW,Express Delivery;
Accepted Payment Currency:USD,EUR,JPY,CAD,AUD,HKD,GBP,CNY,CHF;
Accepted Payment Type: T/T,L/C,MoneyGram,Credit Card,,Cash,Escrow;
Language Spoken:English,Chinese,Spanish,Japanese,Portuguese,German,Arabic,French,Russian,Korean,Hindi,Italian.
6.We promise our customer following items
Support product customization:
We can provide OEM&ODM , Because we have a professional design team.
Reasonable price:
We provide high quality products with competitive price in china,
Low MOQ:
No worry about the low moq, our moq is 1 gram or lower.
Good and efficient service,Fast Delivery
Fast respond save client's time, we promise to reply inquiry in 24 hours including holidays and send quotation sheet and other documents in 48 hours.
Super-good quality
We have strict quality control system .Good reputation in Market , And have the Third party test report is available.
CAS 128270-60-0 Bivalirudin
|
Product Name |
Bivalirudin Trifluoroacetate |
|
Cas No. |
128270-60-0 |
|
Molecular Formula |
C98H138N24O33 |
|
Molecular Weight |
2180.33 |
|
Purity (HPLC) |
99.0%min. |
|
Appearance |
White powder |
|
Single Impurity (HPLC) |
0.5%max |
|
Amino Acid Composition |
±10% of theoretical |
|
Peptide Content (N%) |
≥80.0% |
|
Water Content (Karl Fischer) |
≤8.0% |
|
Acetate Content (HPIC) |
≤12.0% |
|
MS (ESI) |
Consistent |
|
Mass Balance |
95.0~105.0% |
Bivalirudin has a inhibitory effect on soluble and thrombus-bound thrombin in vitro. That effect cannot be affected by
products that are released by platelet, and it can extend plasma activated partial thromboplastin time, thrombin time
and prothrombin time of normal human with a dose-dependent manner. It is suitable for percutaneous coronary
intervention (PCI) unstable angina. In 2010, domestic PCI operation cases reached 300,000. The annual compound
growth rate was over 30%. This showed that sales prospects of bivalirudin after the listing are considerable.
Bivalirudin is a DTI that overcomes many limitations seen with indirect thrombin inhibitors, such as heparin. Bivalirudin
is a short, synthetic peptide that is potent, highly specific, and a reversible inhibitor of thrombin.It inhibits both
circulating and clot-bound thrombin,while also inhibiting thrombin-mediated platelet activation and aggregation.
Bivalirudin has a quick onset of action and a short half-life.It does not bind to plasma proteins (other than thrombin)
or to red blood cells. Therefore it has a predictable antithrombotic response. There is no risk for Heparin Induced
Thrombocytopenia/Heparin Induced Thrombosis-Thrombocytopenia Syndrome (HIT/HITTS).It does not require a
binding cofactor such as antithrombin and does not activate platelets.These characteristics make bivalirudin an ideal
alternative to heparin.
Application & Function
Bivalirudin is indicated for use as an anticoagulant in patients with unstable angina undergoing percutaneous transluminal
coronary angioplasty (PTCA). Bivalirudin with provisional use of glycoprotein IIb/IIIa inhibitor (GPI) is indicated for use as
an anticoagulant in patients undergoing percutaneous coronary intervention (PCI). Bivalirudin is indicated for patients
with, or at risk of HIT/HITTS undergoing PCI. Bivalirudin is intended for use with aspirin and has been studied only in
patients receiving concomitant aspirin.
Clinically experiments prove that bivalirudin is more effective than the current mainstream unfractionated heparin/low
molecular weight heparin and platelet glycoprotein receptor antagonist in applications around PCI.
Especially the risk of bleeding has a significant reduction, and the use safety of anticoagulants is greatly improved:
1. It can significantly reduce the incidence of bleeding in elective PCI patients. The total clinical outcome risk fell 14%.
2. It does not cause antibody-mediated thrombocytopenia.
3. Reversibly bind with thrombin. Short half-life. Hard to develop ischemic and hemorrhagic complications.
4. It is not mainly excreted through the kidneys and can be safely used in patients with renal impairment.
|
test |
specification |
results |
|
|
1. characteristic |
white or almost white powder. |
white powder |
|
|
2. identification a. hplc |
retention time conforms to that of the reference standard |
conforms |
|
|
b. amino acids |
asp: 0.90-1.10;glu: 0.90-1.10 pro: 0.90-1.10;gly: 0.90-1.10 leu: 0.90-1.10;tyr: 0.7-1.05 half-cys: 1.4-2.1;ile: 0.90-1.10 |
conforms |
|
|
3. ph |
3.0-6.0 |
5.0 |
|
|
4. related substances (hplc) |
impurity a≤1.5% |
0.15% |
|
|
impurity b≤1.5% |
0.20% |
||
|
impurity c≤1.5% |
not detected |
||
|
other single impurity≤0.5% |
0.13% |
||
|
total impurities≤5.0% |
0.7% |
||
|
5. acetic acid (hplc) |
6.0%-10.0% |
7.1% |
|
|
6. water(kf) |
nmt 5.0% |
1.4% |
|
|
7. bacterial endotoxins |
less than 300 iu/mg |
conforms |
|
|
8. acn(gc) |
not more than 0.041% |
conforms |
|
|
9. meoh(gc) |
not more than 0.3% |
conforms |
|
|
10. triethylamine(gc) |
not more than 0.032% |
conforms |
|
|
11. assay calculated with reference toanhydrous,aceticacid free substance |
93.0%-102.0% |
98.8% |
|
|
on powder |
nlt 80.0 % |
90.4% |
|
|
nlt 480 iu/mg |
542iu/mg |
||
1. All inquiries will be replied within 12 hours.
2. Dedication to quality, supply & service.
3. Strictly on selecting raw materials.
4. OEM/ODM Available.
5. Reasonable & competitive price, fast lead time.
6. Sample is available for your evaluation & Formulation development.
7. Faster delivery:Sample order in stock and 3-7 days for bulk production.
8.We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS. Or you also can choose your own shipping forwarder
9. After-Sale Service:
1) International Authorized Third-Party Test For The Products You Demand.
2) 30 Days Warranty of quality of goods.
Delivery & Payment Terms
Julong Bio-Tech Co., Ltd. is located in Xi'an City, Shaanxi Province, China. It is a biotechnology enterprise engaged
in the research, development, production and sales of animal and plant extracts, cosmetics, pharmaceutical raw materials
and intermediates. The company has complete experimental facilities. And advanced testing instruments ensure the stability
of product quality from all aspects. The company has a complete sales service system, the products are exported to countries
all over the world, and have won a good international reputation with excellent quality and excellent service.
The company has been adhering to the basic principles of "integrity, quality, service, and win-win" to serve customers,
constantly strict requirements, set goals, and implement win-win development.
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